HIGH POINT, N.C.–(BUSINESS WIRE)–vTv
Therapeutics Inc. (Nasdaq:VTVT) today announced that the Company
will host a key opinion leader (KOL) presentation and webcast focused on
the current state of clinical development in Alzheimer’s disease in New
York City on Thursday, November 16, 2017 from 8:00 am to 10:00 am ET.
The event will feature two speakers, each with extensive experience in
the clinical development in Alzheimer’s:
Dr. Howard Fillit, founding executive director and chief scientific
officer of Alzheimer’s Drug Discovery Foundation, clinical professor
of geriatric medicine, palliative care, and neuroscience at Mt. Sinai
School of Medicine
Dr. Mary Sano, associate dean for clinical research, professor of
Psychiatry, founding member and director of the Alzheimer’s Disease
Research Center at Mt. Sinai School of Medicine
In addition to the presentations, vTv Therapeutics will provide a brief
overview of the company’s ongoing Phase 3 clinical development program
for azeliragon, an orally bioavailable small molecule RAGE antagonist
for patients with mild Alzheimer’s disease.
A live webcast of the event will be available on the Investor page of
vTv’s website at www.vtvtherapeutics.com.
The archived version of the webcast will be available for replay on the Events
& Presentations section of the Investors page of vTv
Therapeutics’ website for 90 days following the event.
vTv discovered and developed azeliragon using its proprietary drug
discovery platform TTP Translational Technology®. A broad range of human
pathologic and experimental biologic investigation suggests that RAGE
activation contributes to the pathogenesis of Alzheimer’s disease.
Sustained Amyloid-β interactions with RAGE at the blood-brain barrier
(BBB) and in neuronal and microglial cells, play potentially major roles
in amyloid plaque formation, neuroinflammation and chronic neural
dysfunction – all hallmarks of Alzheimer’s disease. Azeliragon, also
known as TTP488, is a novel orally active small-molecule antagonist of
STEADFAST, two identical randomized, double-blind, placebo-controlled
Phase 3 trials, is investigating the safety and efficacy of azeliragon
as a potential treatment to slow the decline in cognition and functional
activities for patients with mild Alzheimer’s disease. The 18-month
trial targeted enrollment of 800 patients (400 each for Part A and B).
Part A enrolled patients in the United States and Canada. Enrollment of
Part B additionally included study sites in the United Kingdom, Ireland,
Australia, New Zealand and South Africa. Subjects completing the
STEADFAST study are eligible to enroll in a 24-month open-label
extension trial. STEADFAST is being conducted following agreement with
FDA under the Special Protocol Assessment (SPA) process and the
azeliragon development program has been granted fast track designation.
Enrollment of Part A was completed in September 2016 with data expected
to read out in early 2018. Part B data is expected to read out in late
About vTv Therapeutics
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company
engaged in the discovery and development of orally administered small
molecule drug candidates to fill significant unmet medical needs. vTv
has a pipeline of clinical drug candidates led by programs for the
treatment of Alzheimer’s disease and diabetes as well as treatment of
inflammatory disorders and the prevention of muscle weakness.
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